منابع مشابه
Meiotic behavior of small chromosomes in maize
The typical behavior of chromosomes in meiosis is that homologous pairs synapse, recombine, and then separate at anaphase I. At anaphase II, sister chromatids separate. However, studies of small chromosomes in maize derived from a variety of sources typically have failure of sister chromatid cohesion at anaphase I. This failure occurs whether there is pairing of two copies of a minichromosome o...
متن کاملThe Strandedness of Meiotic Chromosomes from Oncopeltus
Meiotic chromosomes were isolated from male Oncopeltus fasciatus by dissecting the testes under insect Ringer's solution and spreading the living cells on the Langmuir trough. After being dried by the critical point method, preparations were examined under the electron microscope. Chromosomes at all stages of prophase prove to be multistranded. A significant increase in the number of parallel 2...
متن کاملMeiotic chromosomes: it takes two to tango.
Meiosis is a special type of cell division that produces haploid gametes from diploid parental cells. Chromosome number is reduced during meiosis because a single round of DNA replication is followed by two rounds of chromosome segregation (Fig. 1). Fusion of two gametes during sexual reproduction restores the diploid chromosome complement. The second division of meiosis (the equational divisio...
متن کاملPolymer models of meiotic and mitotic chromosomes.
Polymers tied together by constraints exhibit an internal pressure; this idea is used to analyze physical properties of the bottle-brush-like chromosomes of meiotic prophase that consist of polymer-like flexible chromatin loops, attached to a central axis. Using a minimal number of experimental parameters, semiquantitative predictions are made for the bending rigidity, radius, and axial tension...
متن کاملTopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpoint.
Mammalian TopBP1 is a BRCT domain-containing protein whose function in mitotic cells is linked to replication and DNA damage checkpoint. Here, we study its possible role during meiosis in mice. TopBP1 foci are abundant during early prophase I and localize mainly to histone gamma-H2AX-positive domains, where DNA double-strand breaks (required to initiate recombination) occur. Strikingly, TopBP1 ...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2013
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb.2715